I had one interview over WebEx - Cisco's solution for online meetings. Overall, the interview was very conversational and was very down to earth, honest, and concise. Based on other employers, it was a very organized process that I found to be very positive from the initial application to the offer and onboarding.
There were some specific questions regarding my knowledge on various software delivery frameworks and methods such as waterfall and agile. While I couldn't answer all of the questions completely, I demonstrated that where I had knowledge gaps, I could quickly learn and was driven to learn as much as possible to help move my career forward.
When interviewing for a large company, you may not know everything coming into an interview. In the workplace, you will not know everything about a project or a system. The complexity and scale at Cisco can be quite daunting, but if you can demonstrate that you have a willingness and ability to learn and digest concepts quickly, then you will thrive.