My friend recommended that I apply for a job and I sent him my resume. I got a email asking for a phone interview with a recruiter, which went well. It took a long time after that for any response and then I get an invitation for an in person interview. I met with some people on the BD/Sales teams during the first interview, which went well but it was pretty clear that the employees had very little clear vision or product direction. I was surprised by some of their answers to questions I had as to the company and products. I was invited back for a second interview, where I meet more senior level executives and other cross functional members of other departments. Again the interview went well, but again there was very little passion of focus from anyone I interviewed with. Almost universally my questions were answered with generic "twitter is growing fast" answers, but no clear path about what makes twitter different than other companies and how they were going to succeed in a crowded marketplace. I liked the people there and the focus on perfection in existing products and business was clear (very data driven like Google - not surprising since many of the employees worked for Google).
A very huge negative about the whole process is after each interaction Twitter provides very little to no feedback unless you take proactive action and reach out to them. Very unprofessional, especially when interviewing for more senior roles. I eventually received an offer (above market salary, low stock compensation) but turned it down due to my questions about the long term business model and lack of direction at the company.