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Miltenyi Biotec GmbH has signed a purchase contract for a non-harmful, fluorescence-preserving, optical clearing process from the University of Duisburg-Essen, Germany. The invention involves an easy-to-use protocol that allows a safe optical clearing of biological samples for microscopy using an organic solvent-based clearing agent. It is the first method for preparing large biological samples for three-dimensional imaging that completely avoids the use of any harmful agents while maintaining fluorescent staining for high-quality imaging. With the support of PROvendis the university has already registered the new process for international patent approval. The new clearing agent unites the speed of an organic solvent with the harmlessness of water-based clarifiers. Tests have shown that the clearing process, including dehydration, of a mouse brain only takes two days with the new protocol compared to 10-14 days when using water-based protocols.
Miltenyi Biotec has acquired microscopy specialist LaVision BioTec to strengthen its cell analysis and pre-clinical imaging portfolios for cell analysis and add premium expertise in microscopy.